Ring transformations in reactions of heterocyclic compounds with nucleophiles. XI. On the conversion of pteridines into purines.

• NAGEL A.

• PLAS H.C. vander

抄録

2-Methylthio-4, 6, 7-triphenylpteridine (1) is slowly converted by potassium amide in liquid ammonia at -33°into 2-amino-4, 6, 7-triphenylpteridine (2) as the main product and into a ring contraction product which is proved to be 6, 8-diphenyl-2-methylthiopurine (3). The latter is found to be the major product when 4, 6-diphenyl-2-methylthiopteridine (4) and 4, 7-diphenyl-2-methylthiopteridine (5) are treated likewise. The mechanism of the ring contraction is discussed.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 23 (11), 2678-2681, 1975

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390001204172849536
• NII論文ID: 130003767434
• DOI: 10.1248/cpb.23.2678
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/23/11/23_11_2678/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可