Syntheses of potential antimetabolites. XX. Syntheses of 5-carbomethoxymethyl- and 5-methylaminomethyl-2-thiouridine (the "first letters" of some anticodons) and closely related nucleosides from uridine.
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A procedure for the preparation of 5-substituted 2-thiouridines from uridine has been developed, whereby 5-carbomethoxymethyl-(8b) and 5-methylaminomethyl-2-thiouridine (10) (each may be the first letter of certain anticodons of some transfer ribonucleic acids) and the closely related nucleosides [e.g., 5-hydroxymethyl-2-thiouridine (11), 5-cyanomethyl-2-thiouridine (6b), and 5-carbomethoxymethyluridine (8b)] were prepared in satisfactory yields. Acylation of 5-methylaminomethyl-2-thiouridine (10) was also examined and 5-(N-methylbenzamido) methyl-2-thiouridines (12) was prepared and characterized.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 23 (11), 2958-2964, 1975
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204172790784
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- NII論文ID
- 110003621791
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- PubMed
- 1218441
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可