Studies on the syntheses of analgesics. IV. Syntheses of 1,2,3,4-tetrahydro-5H-benzazepine derivatives.

• 澤 陽一

• 加藤 武司

• 増田 亨

• 堀 幹夫

• 藤村 一

抄録

In order to examine more advantageous syntheses and the structure activity relationship, derivatives of 1, 2, 3, 4-tetrahydro-5H-benzazepine were synthesized via two routes from 3, 4-dihydro-1(2H)-naphthalenone. First, these compounds were synthesized via Beckmann rearrangement of 3, 4-dihydro-1(2H)-naphthalenone oximes and second, via 2-(2-cyano-1, 1-dimethylethyl)-4-methoxybenzoic acid. The synthesized compounds were tested for analgesic activity in mice.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 23 (9), 1917-1927, 1975

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390282679145100800
• NII論文ID: 110003622129
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.23.1917
• COI: 1:CAS:528:DyaE28XhslWjug%3D%3D
• ISSN: 13475223
• ISSN: 00092363
• ISSN: http://id.crossref.org/issn/00092363
• PubMed: 1182907
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/23/9/23_9_1917/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1976076452
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可