Effect of phospholipid on the release of beta-lipoprotein in orotic acid-induced fatty liver.

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The content of liver lipids and protein, and serum beta-lipoprotein were determined in control and orotic acid-fed rats. Further, the effect of phosphatidylcholine on the release of beta-lipoprotein from liver slices into the incubation medium was examined in both groups. Results are summarized as follows : 1. The amount of liver glycerides increased significantly by ingestion of orotic acid, but liver phospholipid and protein decreased. 2. A 50 per cent depression of the content of serum beta-lipoprotein was observed in rats fed orotic acid. 3. The release of beta-lipoprotein from liver slices decreased when orotic acid was added to the diet. This decrease was partly restored by the addition of phosphatidylcholine. 4. When liver slices were pre-treated with phospholipase C, the amount of released beta-lipoprotein increased in both control and orotic acid-fed rats. The treated liver slices from orotic acid-fed rats released the same amount of lipoprotein as the control by the addition of phosphatidylcholine. From these observations, phosphatidylcholine appears to take part in the release of beta-lipoprotein. Accordingly, it was concluded that fatty liver induced by orotic acid resulted from the impaired phosphatidylcholine synthesis in the liver.

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