Synthetic chemotherapeutic agents. I. Synthesis of 2-substituted thiazolo(5,4-f)quinoline derivatives.(1).

• 堂森 廉三

• 門矢 静夫

• 高村 功

• 鈴木 範夫

抄録

By using 6-aminobenzothiazoles as starting meterial, a series of 2-substituted 6-ethyl-6, 9-dihydro-9-oxothiazolo [5, 4-f] quinoline-8-carboxylic acids has been prepared through successive steps of, e.g. condensation with diethyl ethoxymethylenemalonate, Gould-Jacobs reaction, N-alkylation and hydrolysis. These compounds were evaluated for antibacterial activities in vitro. The 2-chloro derivative (10d) showed nearly the same activity with nalidixic acid.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 24 (1), 130-135, 1976

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390001204172571136
• NII論文ID: 110003634811
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.24.130
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 1269056
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/24/1/24_1_130/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1976106901
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可