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The effect of thyrocalcitonin (TCT) on the calcium content of liver slices has been studied. At 30 min incubation period, TCT significantly (p<0.01) increased the accumulation of calcium in the concentration range from 0.1 to 8.0 mU/ml with half-maximal concentration occurring at about 0.1 mU/ml. During the 60 min incubation period, the effect of TCT on the liver calcium accumulation was additively enhanced. On the other hand, the radiocalcium (45CaCl3) efflux in the absence of the hormone increased linearly during the incubation period. The radiocalcium efflux in the presence of the hormone increased later with time than that in the absence of the hormone, and the inhibition of efflux was 25% of the control (p<0.01). These data suggest that TCT increased calcium accumulation in the liver cells by inhibiting the efflux of calcium.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 24 (1), 159-161, 1976
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679150441856
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- NII論文ID
- 110003634815
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- PubMed
- 1269058
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可