Chemical and biochemical studies on carbohydrate esters. III. Antitumor activity of unsaturated fatty acids and their ester derivatives against Ehrlich ascites carcinoma.

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Antitumor activity of some unsaturated fatty acids and the ester derivatives was tested with Ehrlich ascites carcinoma in mice. The compounds examined were A) 10-undecenoic, elaidic, oleic, linoleic, and linolenic acids, B) methyl esters of oleic, linoleic, and linolenic acids, C) 1-O-acyl-β-D-glucopyranose tetraacetates derived from oleic, linoleic, and linolenic acids, and D) sucrose monoesters prepared from the fatty acids belonging to group A. The agent to be tested was administered to mice by intraperitoneal injection, and the effect was evaluated with total packed cell volume ratio on the 7th day after tumor implantation. The free fatty acids having 18 carbon atoms were all highly active, but 10-undecenoic acid proved to show no activity. All members of groups B and C were completely ineffective. The sucrose monoelaidate, in particular, and the sucrose monooleate exerted strong effect, whereas other sucrose monoesters exhibited only slight or negative activity. Some basic properties of the two types of carbohydrate esters employed are also described.

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