Syntheses of dibenzo(b,f)azonines and dibenzo(b,g)azecines through ring expansion of 1-substituted isoquinolines.

• 加納 慎蔵

• 小見山 映二

• 高萩 洋子

• 渋谷 皓

抄録

The reaction of 1-(2-bromo-4, 5-methylenedioxyphenethyl)-1, 2, 3, 4-tetrahydro-6-hydroxy-7-methoxy-2-methylisoquinoline (13) with sodium methylsulfinylmethanide gave the dibenzo [b, g] azecine (14). The 1-benzyl analog possessing a methyl group at the 3-position was transformed to the 6, 13-disubstituted dibenzo [b, f] azonine (33) under the similar conditions. 33 was converted to the corresponding 6, 13-dimethyl derivative (35). Hydrogenolysis of the N-methyl-dibenzo [a, f] quinolizinium iodide (23) over Adams catalyst was also examined to give the dibenzo [b, g] azecine (24).

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 24 (4), 648-654, 1976

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390001204172715904
• NII論文ID: 110003635026
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.24.648
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/24/4/24_4_648/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1977059296
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可