Analytical studies on mepirizole and its metabolites. III. Gas chromato-graphic determination of mepirizole and its metabolites in biological fluids.
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Highly sensitive techniques for the quantitative determination of mepirizole (I) and its metabolites are described. The compounds were first extracted from rat serum with dichloromethane, and they were converted to their respective trifluoroacetyl derivatives in isopropyl ether, which could be detected by a gas chromatograph equipped with an electron capture detector. The approximately linear relationships existed between the quantities of these compounds and the sensitivities to electron capture detector in the range of the serum levels as low as several hundred ng. The structures of the trifluoroacetylated derivatives of the metabolites were identified by gas chromatography-mass spectrometry.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 24 (4), 808-812, 1976
公益社団法人 日本薬学会
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詳細情報
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- CRID
- 1390001204172707968
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- NII論文ID
- 110003635049
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- PubMed
- 949820
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可