Studies on prostaglandins. III. Synthesis of bicyclo(4.3.0)nonane derivatives.

• 犬飼 紀喜

• 岩本 英徳

• 田村 隼也

• 柳沢 勲

• 石井 吉雄

• 高木 徳一

• 富岡 健一

• 村上 増雄

抄録

3-(4-Carboxybutylidene)-7α, 9α-dihydroxy-4-hexyl-1βH, 6αH-bicyclo [4.3.0] nonane (III) and 3-(4-carboxybutylidene)-7α, 9α-dihydroxy-4-(1-hydroxyhexyl)-1βH, 6αH-bicyclo [4.3.0]-nonane (IV) were synthesized as prostaglandin-derivatives which were related to steroids. Preliminary in vitro studies on isolated guinea pig ileum have shown that IV possessed weakly PG-like contraction activity (1/300 of PGF_2α) and III did not possess the PG-like activity.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 24 (6), 1414-1417, 1976

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390282679150397056
• NII論文ID: 110003635156
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.24.1414
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 1021296
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/24/6/24_6_1414/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1977081078
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可