Pyridazines. II. Intramolecular cycloaddition of 3-substituted-6-(2-(2-methylallyl)phenoxy)pyridazines.

• 城島 輝臣

• 竹柴 英雄

• 乙 孝夫

抄録

Heating of 3-phenyl-, 3-methyl, and 3-chloro-6-[2-(2-methylallyl) phenoxy] pyridazine in diethylaniline or without a solvent afforded 2-substituted-9a-methyl-1, 9a-dihydroxanthenes, which are previously unknown group of compounds. The mechanism of this reaction may be explained by an intramolecular cycloaddition between pyridazine nucleus and the allylic side chain to give the (4+2)π adduct followed by N₂ elimination. Similarly, cyclization of 1-phenyl-4-[2-(1-methylallyl)-1-naphthyloxy] phthalazine gave 5-phenyl-6a-methyl-6a, 12a-dihydro-7H-benzo [c] xanthene.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 24 (7), 1581-1587, 1976

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390282679150280320
• NII論文ID: 110003662193
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.24.1581
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/24/7/24_7_1581/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1977098133
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可