Studies on the syntheses of heterocyclic compounds. DCXCII. A novel synthetic route to phthalideisoquinoline and spirobenzylisoquinoline type alkaloids.

• 亀谷 哲治

• 大沢 立志

• 平田 尚司

• / 井原 正隆

• 福本 圭一郎

• FUKUMOTO KEIICHIRO

抄録

Permanganate oxidation of 12-chloro-5, 6, 7, 7a-tetrahydro-2, 3, 9, 10-tetramethoxy-7-methylindeno [2, 1-α] [3] benzazepine (5) in the presence of piperidine gave the diketospirobenzylisoquinoline (11) and the lactone (15), the latter of which was converted into erythro-and threo-phthalideisoquinoline (16 and 17). 2, 3-Dihydro-7, 8-dimethoxy-5-(2, 3-dimethoxybenzoyl)-3-methyl-1H-3-benzazepine (4) was prepared from N-β-(3, 4-dimethoxyphenethyl)-2, 3-dimethoxyphenylacetamide (26) in four steps.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 25 (2), 321-326, 1977

  公益社団法人 日本薬学会

キーワード

• 2, 3-dihydro-7, 8-dimethoxy-5-(2, 3-dimethoxybenzoyl)-3-methyl-1H-3-benzazepine

詳細情報

• CRID: 1390282679147853952
• NII論文ID: 110003622403
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.25.321
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/25/2/25_2_321/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1978031584
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可