Synthetic antibacterials. VII. N-(1,8-naphthyridin-7-yl)methylenamine derivatives.

• 西垣 貞男

• 水島 規子

• 千賀 慶太郎

抄録

Treatment of ethyl 1, 4-dihydro-1-ethyl-7-methyl-4-oxo-1, 8-naphthyridine-3-carboxylate (1) with selenium dioxide afforded a mixture of ethyl 1, 4-dihydro-1-ethyl-7-formyl-4-oxo-1, 8-naphthyridine-3-carboxylate (2) and 1, 4-dihydro-1-ethyl-7-formyl-4-oxo-1, 8-naphthyridine-3-carboxylic acid (3). Condensation of 2 or 3 with respective amines provided the corresponding N-(1, 4-dihydro-3-ethoxycarbonyl-1-ethyl-4-oxo-1, 8-naphthyridin-7-yl) methylenamine (4-15) and N-(3-carboxy-1, 4-dihydro-1-ethyl-4-oxo-1, 8-naphthyridin-7-yl) methylenamine (16-27), respectively. These compounds were tested for in vitro antibacterial activity.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 25 (2), 349-352, 1977

  公益社団法人 日本薬学会

キーワード

• 1, 4-dihydro-1-ethyl-7-formyl-4-oxo-1, 8-naphthyridine-3-carboxylic acid

詳細情報

• CRID: 1390001204171147136
• NII論文ID: 110003622407
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.25.349
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 852097
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/25/2/25_2_349/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1978031774
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可