Phosphorus in organic synthesis. XVI. Diphenyl phosphorazidate (DPPA) and diethyl phosphorocyanidate (DEPC). Two new reagents for the preparation of thiol esters from carboxylic acids and thiols.

• 横山 祐作

• 塩入 孝之

• 山田 俊一

抄録

Thiol esters were directly and conveniently prepared from carboxylic acids and thiols with diphenyl phosphorazidate (DPPA) or diethyl phosphorocyanidate (DEPC) in the presence of triethylamine in dimethylformamide solution. Both aromatic and aliphatic acids easily react with both aromatic and aliphatic thiols. The method can be efficiently applied to the thiol ester synthesis with little racemization, demonstrated by the formation of ethyl thiol ester of benzoyl-L-leucine.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 25 (9), 2423-2429, 1977

  公益社団法人 日本薬学会

キーワード

• penicillins

詳細情報

• CRID: 1390001204170315648
• NII論文ID: 110003622740
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.25.2423
• COI: 1:CAS:528:DyaE1cXitFCgsg%3D%3D
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/25/9/25_9_2423/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1978106703
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可