Biological effects of furosemide in relation to its disposition in rabbits.

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The purpose of this study was to represent quantitatively the relationship between the time course of pharmacological response and drug disposition data after intravenous administration of furosemide in rabbits. After administration of furosemide, urine flow rate, urinary excretion rate of Na+ and K+ were measured as well as excretion rate of intact drug and drug plasma level. From the data observed, a simplified simulation model was constructed and theoretical values were calculated by the model. Calculated values showed reasonable coincidence with the observed values. The urinary excretion rate of furosemide which was used in place of the plasma level, for the practical purposes, was able to correlate quantitatively with diuretic response ; urine flow rate and electrolyte excretion rate.

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