New sulfhydryl compounds with potent antihypertensive activities.

• 三田 周

• 岩尾 順一

• 大矢 正雪

• 千葉 剛久

• 磯 正

抄録

(4R)-3-(Mercaptoacyl)-4-thiazolidinecarboxylic acids (III) were synthesized and their inhibitory activities against angiotensin-converting enzyme (ACE) were examined in vitro and in vivo. (4R)-3-[(2S)-3-Mercapto-2-methylpropanoyl]-4-thiazolidinecarboxylic acid (4a) was the most potent orally active inhibitor of ACE among the derivatives and its activity was almost same as that of (2S)-1-[(2S)-3-mercapto-2-methylpropanoyl] proline (8).

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 26 (4), 1333-1335, 1978

  公益社団法人 日本薬学会

キーワード

• antihypertensive agent

詳細情報

• CRID: 1390282679147650688
• NII論文ID: 110003623136
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.26.1333
• COI: 1:CAS:528:DyaE1cXlsVKrs7Y%3D
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 207454
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/26/4/26_4_1333/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1979071062
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可