Radical methylation and radical hydroxymethylation of N-substituted quinoline derivatives.

• 糸川 秀治

• 亀山 省司

• 稲葉 利和

• 田崎 敏夫

• 春田 龍二

• 川添 豊

• 前田 満和

抄録

N-substituted quinoline derivatives such as 〓N⁺-Me, 〓N⁺O^-, 〓N⁺-NH^- were derived to methyl substituted compound at C-2 and/or C-4 by radical methylation and by radical hydroxymethylation. In the case of radical methylation and radical hydroxymethylation of quinoline 1-oxides, carbon at C-2 was preferentially nucleophilic than at C-4. Useful way to synthesize the alkyl substituted derivatives at C-2 selectively was to proceed the alkylation after forming N-oxide.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 26 (4), 1015-1020, 1978

  公益社団法人 日本薬学会

キーワード

• quinoline 1-oxide

詳細情報

• CRID: 1390282679146183296
• NII論文ID: 110003623083
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.26.1015
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/26/4/26_4_1015/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1979071709
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可