Studies on peptides. LXXVI. Synthesis of kassinin, a new frog skin peptide.

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Kassinin, a dodecapeptide amide isolated by Erspamer et al. from the skin of Kassina senegalensis, was synthesized by deprotection of Z (OMe)-Asp (OBzl)-Val-Pro-Lys (Z)-Ser-Asp (OBzl)-Gln-Phe-Val-Gly-Leu-Met (O)-NH2 with methanesulphonic acid, followed by reduction of the Met (O) residue to Met with 2-mercaptoethanol. The contractile activity of synthetic kassinin in isolated guinea-pig ileum was 0.4 of that of synthetic substance P.

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