1-Indancarboxylic acids. III. Chemical modifications of antiinflammatory 4-aroyl-1-indancarboxylic acids.

DOI Web Site PubMed

この論文をさがす

抄録

For elucidating the receptor site of antiinflammatory arylacetic acids, some modifications were made on 4-aroyl-1-indancarboxylic acids (Ia-d) which have potent antiinflammatory activities. Modifications were introduced on the characteristic parts of I and 1-methylated derivatives (VIII), tetralin analogs (XVIII) and benzyl analogs (XXX) of I were prepared. However, these compounds showed weaker activities than the parent compound I. The result suggests that 1-indancarboxylic acid is the pharmacologically effective derivative of arylacetic acid.

収録刊行物

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ