Synthesis and antiandrogenic activity of 16.BETA.-substituted-17.BETA.-hydroxysteroids.

• 後藤 義一

• 吉岡 晃一

• 平賀 謙太郎

• 増岡 通夫

• 中山 亮

• 三木 卓一

抄録

In order to examine the antiandrogenic activity, a series of 16β-substituted-17β-hydroxysteroids (9 and 16) were synthesized by stereoselective introduction of β-substituents at position 16 of steroids. The corresponding 6-chloro-16β-substituted-17β-hydroxysteroids (20 and 28) and 1, 2α-methylene derivative (36) were also prepared. Among these new steroids synthesized, 17β-hydroxy-16β-ethylestr-4-en-3-one (9b : TSAA-291) was found to have the most potent antiandrogenic activity with very weak side effects and also found to be useful for a treatment of the benign prostatic hypertrophy.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 26 (6), 1718-1728, 1978

  公益社団法人 日本薬学会

キーワード

• prostatic hypertrophy

詳細情報

• CRID: 1390001204170992384
• NII論文ID: 110003623196
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.26.1718
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 699195
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/26/6/26_6_1718/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1979071841
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可