Hypocholesterolemic activities of LK-903 and clofibrate in miniature pigs, cynomolgus monkeys and beagle dogs.
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The hypocholesterolemic activities of LK-903 (α-methyl-p-myristyloxycinnamic acid-1-monoglyceride) and clofibrate were examined in miniature pigs (OHMINI-875) and beagle dogs. When administered in the diet for one week, LK-903 and clofibrate were active in the miniature pig at doses of 5 and 10 mg/kg/day, respectively, whereas the two drugs showed no hypocholesterolemic activity in the beagle dog. In cynomolgus monkeys, LK-903 showed a hypocholesterolemic effect, but serum cholesterol depression was less marked than in the miniature pig.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 26 (8), 2454-2457, 1978
公益社団法人 日本薬学会
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詳細情報
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- CRID
- 1390001204171073664
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- NII論文ID
- 110003623314
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- NII書誌ID
- AA00602100
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- COI
- 1:CAS:528:DyaE1cXlvFWitr4%3D
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- ISSN
- 13475223
- 00092363
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- PubMed
- 101309
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可