Studies of nucleosides and nucleotides. LXXXII. Cyclonucleosides. (39). Synthesis and properties of 2'-halogeno-2'-deoxyadenosines.

• 池原 森男

• 三木 弘子

抄録

9-(2'-O-Methanesulfonyl- or trifluoromethanesulfonyl-3', 5'-di-O-tetrahydropyranyl-β-D-arabinofuranosyl) adenine (Ia, b) were reacted with lithium chloride or tetrabutylammonium halide to yield 2'-halogeno-2'-deoxy compounds (IIa-d). These halogeno compounds were deprotected with 80% acetic acid to give 2'-chloro-, 2'-bromo-, 2'-fluoro and 2'-iodo-2'-deoxyadenosine (IVa-d) in overall yields of 12-25% from the compound I. Ultraviolet absorption properties, ¹H and ¹³C-nuclear magnetic resonance spectral properties were recorded on the compounds IVa-d.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 26 (8), 2449-2453, 1978

  公益社団法人 日本薬学会

キーワード

• ^<13>C-NMR

詳細情報

• CRID: 1390282679145361408
• NII論文ID: 110003623313
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.26.2449
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/26/8/26_8_2449/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1979094127
• 本文言語コード: en
• データソース種別:
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• 抄録ライセンスフラグ: 使用不可