Studies on the constituents of Buddleja species. II. Buddledin C, D and E, new sesquiterpenes from Buddleja davidii Franch.

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Further toxic principle, buddledin C, and two additional sesquiterpenes, buddledin D and E, have been isolated from the root bark of Buddleja davidii FRANCH. The structures of buddledin C and D have been determined to be 3 and 4 by chemical transformation of buddledin A into buddledin D and dihydrobuddledin C (6), and by comparisons of their spectral data with those of buddledin A and its cis-isomer (8), which was obtained by the photoisomerization of 1. Structure 5 has been assigned for buddledin E by its spectral data and deuteration experiment.

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