A new prostaglandin synthon from the 4-oxatricyclo[4.3.0.03,7]non-8-ene system. A total synthesis of (.+-.)-prostaglandin F2.ALPHA..

• 高野 誠一

• 久保寺 登

• 岩田 裕光

• 小笠原 国郎

抄録

The synthesis of a new prostaglandin synthon (14) from 5-trichloromethyl-4-oxatricyclo [4. 3. 0. 0^{3, 7}] non-8-ene (2) and its conversion to prostaglandin F_2α (21) are described. Compound (2) was transformed into the acetylene derivative (5) which was then led to the C-9 acetylene lactone (14) via a 6-step, 8-stage reaction. A new synthesis of (±)-prostaglandin F_2a (21) was completed through a 5-step reaction starting from the C-9 lactone (14).

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 27 (11), 2582-2588, 1979

  公益社団法人 日本薬学会

キーワード

• silver perchlorate

詳細情報

• CRID: 1390001204165152768
• NII論文ID: 110003623504
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.27.2582
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/27/11/27_11_2582/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1980111140
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可