Stereoselective reactions. III. A highly efficient method for the asymmetric synthesis of 2-alkylcycloalkanones via chiral chelated lithioenamines.

DOI Web Site 被引用文献2件

この論文をさがす

抄録

A novel method was devised for the asymmetric synthesis of 2-alkylcycloalkanones (10) by metalation and alkylation of chiral cyclic imines (8), using an optically active α-amino acid tert-butyl ester (7) as a chiral source. The present method provides 2-alkylcycloalkanones (10) of unequivocally predictable absolute configuration in quite high enantiomeric purities, allowing easy recovery of the chiral reagent without any racemization for reuse. The present method is also shown to be applicable for the creation of an asymmetric quaternary carbon atom, as exemplified in the synthesis of 2-methyl-2-phenylcycloalkanones (13). The mechanism of the reaction is proposed.

収録刊行物

被引用文献 (2)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ