Inclusion complex of acetohexamide with .BETA.-cyclodextrin and its hypoglycemic activity in rabbit.

• 上釜 兼人

• 松尾 直樹

• 平山 文俊

• 山口 辰哉

• 今村 順茂

• 一番ヶ瀬 尚

抄録

Inclusion complex formation of acetohexamide with β-cyclodextrin in water and in solid state was ascertained by solubility method, circular dichroism spectroscopy, and powder X-ray diffractometry. A solid complex of acetohexamide with β-cyclodextrin in 1 : 2 molar ratio was prepared, and its dissolution behavior in water and hypoglycemic activity in rabbit were examined. Improved dissolution characteristic of acetohexamide by inclusion complexation resulted in potentiation of the reduction in blood glucose levels in rabbit, which may be due to the increase in absorption of the drug.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 27 (2), 398-402, 1979

  公益社団法人 日本薬学会

キーワード

• blood glucose level in rabbit

詳細情報

• CRID: 1390282679145402112
• NII論文ID: 110003623620
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.27.398
• COI: 1:CAS:528:DyaE1MXitFSjtLo%3D
• ISSN: 13475223
• ISSN: 00092363
• ISSN: http://id.crossref.org/issn/00092363
• PubMed: 445676
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/27/2/27_2_398/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1979130632
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可