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In comparing the effect of ginseng principle on the activity of pyruvate kinase (EC 2. 7. 1. 40), there was a marked difference among various diet groups. Administration of the extract (fraction 5) from the roots of Panax ginseng C. A. MEYER increased the activity of hepatic pyruvate kinase in rats fed on a laboratory pellet chow. Maximum increase in the enzyme activity was observed 1 hr after the administration of ginseng principle, and it was found that this response depended on the amount of fraction 5 administered to rats. However, rise of the enzyme activity due to ginseng treatment did not seem to involve de novo protein synthesis which requires mRNA production. In contrast, when the diet contained an excess of carbohydrate, ginseng treatment resulted in a decreased enzyme level, and the elimination of food resulted in the loss of the effect of ginseng principle.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 27 (2), 419-423, 1979
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679149439232
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- NII論文ID
- 110003623623
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- PubMed
- 445678
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可