Synthesis of enantiomeric pairs of Vicinal-diols from L-.ALPHA.-amino acids by the use of organolithium reagents: Its application to optically active epoxyterpene synthesis.
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Abstract
Reaction of (S) (-)-α-tosyloxy acid ((S)(-)-3) with methyl- or n-butyllithium was found to afford (R)(+)-vicinal (vic)-diol ((R)(+)-4) in an excellent yield with almost full inversion. On the other hand, when (S)(-)-α-hydroxy acid ester ((S)(-)-5) was allowed to react with methyl- or n-butyllithium, (S)(-)-vic-diol ((S)(-)-4) was obtained in an excellent yield with full retention. Since (S)(-)-3 and (S)(-)-5 are both derivable from L-phenylalanine (L-1), it has become possible to obtain an enantiomeric pair of vic-diols from L-1. Plausible formation mechanism for (R)(+)-4 from (S)(-)-3 was proposed. The utility of optically active vic-diols in natural product synthesis was also visualized by preparing the novel synthetic intermediate for epoxyterpene synthesis ((S)(-)-6) from (S)(-)-4a.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 27 (3), 758-764, 1979
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390001204170722304
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- NII Article ID
- 110003662245
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- NII Book ID
- AA00602100
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- COI
- 1:CAS:528:DyaE1MXkslCju7s%3D
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- ISSN
- 13475223
- 00092363
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed