Studies on benzhydryl derivaties. I. Synthesis and anti-inflammatory activity.

• 永富 光

• 安藤 和子

• 川崎 正弘

• 安井 凡平

• 三木 康義

• 竹村 庄司

抄録

A series of N-diphenylmethyl derivatives of glycine was synthesized and their anti-inflammatory and some other pharmacological properties were studied. The inhibition of carrageenin edema-induction and the protection of albumin from heat denaturation by these derivatives were studied in relation to the substituents in one of the phenyl groups. The most potent compounds, 3, 4-dichloro-(Compd. 22) and 4-fluoro-(Compd. 16) diphenylmethylglycine derivatives, showed the higher activity in carrageenin-edema and weaker toxicity tested by gastric irritation and acute toxicity study than 2-(4-isobutyl-phenyl) propionic acid (ibuprofen). Compd. 16 showed the significant and interesting synergic effect by co-administration with cortisone acetate in the various tests of anti-inflammatory activity.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 27 (4), 1021-1029, 1979

  公益社団法人 日本薬学会

キーワード

• synergic effect

詳細情報

• CRID: 1390282679149064960
• NII論文ID: 110003662285
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.27.1021
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 476856
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/27/4/27_4_1021/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1980035337
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可