Asymmetric reduction of various ketones with the sodium salts of .ALPHA.-amino acid borane complexes.

• 海野 徳英

• 岩隈 建男

• 伊藤 信夫

抄録

The sodium salts of amino acid borane complexes (1) produced from equimolar amount of NaBH₄ and optically active α-amino acids in tetrahydrofuran at room temperature reduced various ketones to the corresponding optically active alcohols (2-62% optical yield). Sodium prolinate borane complex (2) gave the best results. Asymmetric reduction of (3) with sodium L-prolinate borane complex (2) followed by catalytic hydrogenolysis of benzyl and carbobenzoxy groups gave (4), a cardiotonic agent, in 62% optical yield.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 27 (6), 1479-1481, 1979

  公益社団法人 日本薬学会

キーワード

• cardiotonic agent

詳細情報

• CRID: 1390001204169234560
• NII論文ID: 110003623680
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.27.1479
• COI: 1:CAS:528:DyaL3cXit1Wqtg%3D%3D
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/27/6/27_6_1479/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1980059854
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可