Synthesis and immunological effects of thymosin .ALPHA.1 and its fragments on inhibitory factor in minimal change nephrotic syndrome.

• 安孫子 敬

• 小野寺 育子

• 関野 宏

抄録

The octacosapeptide corresponding to the entire amino acid sequence of thymosin α₁ was synthesized using the catalytic hydrogenation procedure at the final deprotection step. The depressed E-rosette forming capacity of lymphocytes caused by a serum factor from a patient in the active stage of MCNS was significantly restored when the lymphocytes were incubated with thymosin α₁. The relative potency of the decapeptide fragment (positions 19-28) was 1.04 and that of the pentadecapeptide fragment (positions 14-28) was 9.83 based on synthetic thymosin α₁ (100.00) as a standard.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 28 (12), 3542-3548, 1980

  公益社団法人 日本薬学会

キーワード

• HOBT-DCC method

詳細情報

• CRID: 1390282679141144960
• NII論文ID: 110003623879
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.28.3542
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 7226295
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/28/12/28_12_3542/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1982073019
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可