Enkephalin analogs containing the dipeptide unit Tyr-Arg (kyotorphin).

• 窪田 実

• 長瀬 脩

• 天野 博夫

• 高木 博司

• 矢島 治明

抄録

Eight Met- and Leu-enkephalin analogs substituted with L- or D-Arg at position 2 were synthesized using N^G-mesitylene-2-sulfonylarginine. Among them, H-Tyr-D-Arg-Gly-Phe-Met-OH was found to possess an analgesic effect 2.4 times higher than that of morphine on a molar basis, when injected intracisternally. This compound was also found to produce analgesia when administered intravenously.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 28 (9), 2580-2586, 1980

  公益社団法人 日本薬学会

キーワード

• analgesic effect

詳細情報

• CRID: 1390282679144255360
• NII論文ID: 110003624068
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.28.2580
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 7460094
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/28/9/28_9_2580/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1981177539
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可