Synthesis of the eicosapeptide corresponding to the N-terminal amino acid sequence of the major component of human lymphoblastoid interferon.

• 安孫子 敬

• 小野寺 育子

• 関野 宏

抄録

An eicosapeptide, H-Ser-Asp-Leu-Pro-Gln-Thr-His-Ser-Leu-Gly-Asn-Arg-Arg-Ala-Leu-Ile-Leu-Leu-Ala-Gln-OH, corresponding to the N-terminal amino acid sequence of the major component of human lymphoblastoid interferon was synthesized by a conventional method. The final deprotected peptide was purified by gel filtration on Sephadex G-25 and then by partition chromatography on Sephadex G-25. The eicosapeptide at a dose of 100 μg/ml inhibited the incorporation of ³H-thymidine into DNA of PHA-induced lymphocytes by about 15%.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 29 (5), 1390-1397, 1981

  公益社団法人 日本薬学会

キーワード

• ^3H-thymidine incorporation

詳細情報

• CRID: 1390001204162733312
• NII論文ID: 110003633831
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.29.1390
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 6170469
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/29/5/29_5_1390/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1982193005
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可