Structure determination of violaceol-I and -II, new fungal metabolites from a strain of Emericella violacea.

• YAMAZAKI MIKIO

• MAEBAYASHI YUKIO

Abstract

A toxic metabolite, violaceol, which was isolated from the fungus, E. violacea, was found to be a mixture of two isomers. Violaceol-I (3) and -II (4) were isolated as tetraacetates through acetylation and preparative thin layer chromatography. The structures of violaceol-I and -II were determined as shown in Fig. 1 and 2, mainly by the analysis of the ¹H- and ¹³C-nuclear magnetic resonance spectral data, especially the ¹³C-¹H indirect spin coupling constants. Violaceols were lethal to mice and exhibited weak antimicrobial activity.

Journal

• Chemical and Pharmaceutical Bulletin

  Chemical and Pharmaceutical Bulletin 30 (2), 514-518, 1982

  The Pharmaceutical Society of Japan

Keywords

• ^<13>C-<SUP>1</SUP>H indirect spin coupling

Details

• CRID: 1390282679142985984
• NII Article ID: 110003634308
• NII Book ID: AA00602100
• DOI: 10.1248/cpb.30.514
• COI: 1:CAS:528:DyaL38XitFChuro%3D
• ISSN: 13475223
• ISSN: 00092363
• ISSN: http://id.crossref.org/issn/00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/30/2/30_2_514/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1982208839
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed