Thermodynamic properties of polymorphs of tolbutamide.

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Thermodynamic values for two polymorphic forms of tolbutamide (form A and form B) were calculated on the basis of solubility determination and differential scanning calorimetry. The transition temperature and the heat of transition were estimated to be 93.3°C, and 230 cal/mol by the former method, and 98.5°C, and 255 cal/mol by the latter method. The dissolution rate was only slightly affected by the polymorphic form.

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