Michael addition of (1H)pyrrole.

• 的場 勝英

• 山崎 高應

抄録

[1H] Pyrrole (IIa) was reacted with 2-chloroethyl tosylate (III) in acetone in the presence of potassium hydroxide (condition A) to give 1-(4-oxo-2-methyl-2-pentyl) [1H]-pyrrole (IV) instead of 1-(2-tosyloxyethyl) [1H] pyrrole (IIb). IV was obtained from the reaction of IIa and mesityl oxide (V) in acetonitrile in the presence of potassium hydroxide (condition B). With IIa under condition B, crotononitrile, ethyl crotonate, and 4, 4-dimethyl-2-cyclohexenone (IX) gave 3-(1-[1H] pyrrolyl) butyronitrile (VIIa), 3-(1-[1H] pyrrolyl) butyric acid (VIIIa), and a mixture of 4, 4-dimethyl-3-(1-[1H] pyrrolyl) cyclohexanone (X) and 1-cyanomethyl-4, 4-dimethyl-3-(1-[1H] pyrrolyl) cyclohexanol (XI), respectively.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 30 (7), 2586-2589, 1982

  公益社団法人 日本薬学会

キーワード

• pyrrole N-alkylation

詳細情報

• CRID: 1390001204166662912
• NII論文ID: 110003634643
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.30.2586
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/30/7/30_7_2586/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1982209349
• 本文言語コード: en
• データソース種別:
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  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可