Disturbing effect of cationic amphiphilic drugs on phospholipid asymmetry of the membrane lipid bilayer of human erythrocytes.

• 田村 明

• 守脇 尚子

• 藤井 達三

抄録

After treatment of human erythrocytes at 37°C with a cationic amphiphilic drug (one of various tertiary amine phenothiazines, primaquine or n-decylamine), up to 45% of the membrane phosphatidylethanolamine (PE) was degraded by added phospholipase A₂ from bee venom (untreated erythrocytes, 1-2%) and about 35% of the PE could be labelled by trinitrobenzenesulfonate (untreated erythrocytes, about 14%). Pancreatic phospholipase A₂, which is virtually unable to hydrolyze the phospholipids of intact erythrocytes, degraded significant amounts of phosphatidylcholine and PE in the erythrocyte membrane pretreated with the above drugs. These results suggest that cationic drugs in general may alter the protein-lipid interaction of the membrane and thus release the inner layer phospholipid PE from possible locational restriction under the influence of certain proteins.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 31 (5), 1692-1697, 1983

  公益社団法人 日本薬学会

キーワード

• membrane phospholipid asymmetry

詳細情報

• CRID: 1390001204163230592
• NII論文ID: 130003769276
• DOI: 10.1248/cpb.31.1692
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 6616719
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/31/5/31_5_1692/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可