1,3-Oxazines and related compounds. VI. Synthesis and some reactions of 2,6-disubstituted 4H-1,3-thiazin-4-ones.

• 山本 豊

• 大西 修平

• 東 裕

抄録

Various of 2, 6-disubstituted 4H-1, 3-thiazin-4-ones (5) were synthesized by successive treatment of N-acylacetylcarboxamides with acid (such as 70% perchloric acid or fluorosulfonic acid) and hydrogen sulfide. Reactions of 5 were investigated ; ammonolysis with ethanolic ammonia gave the corresponding pyrimidin-4-ones; hydrolysis of 2-alkyl-1, 3-thiazine derivatives yielded ring-opened N-acyl-β-mercaptocrotonamides ; reduction with NaBH₄ or LiAlH₄ afforded 3, 4-dihydro-2H-1, 3-thiazin-4-one derivatives.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 31 (6), 1929-1935, 1983

  公益社団法人 日本薬学会

キーワード

• N-acyl-β-mercaptocrotonamide

詳細情報

• CRID: 1390282679141993600
• NII論文ID: 130003769361
• DOI: 10.1248/cpb.31.1929
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/31/6/31_6_1929/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可