Effects of actinomycin D and cycloheximide on the activities of catalase and D-amino acid oxidase in the rat kidney cortex during sodium restriction.

• 森本 史郎

• 安部 りょう子

抄録

This study was carried out to determine whether actinomycin D and cycloheximide affect the activities of catalase and D-amino acid oxidase in the rat kidney cortex under conditions of sodium restriction. Animals were maintained on a sodium-deficient diet and injected intra-peritoneally with actinomycin D or cycloheximide. Low sodium intake for 7d resulted in increased activities of catalase and D-amino acid oxidase in the kidney cortex. Daily adminis-tration of actinomycin D (20μg·kg^-1·d) or cycloheximide (80μg·kg^-1·d) with the intake of sodium-deficient diet for 7d had no influence on the amount of protein in the kidney cortex, but preferentially prevented the elevation of the activities of catalase and D-amino acid oxidase by sodium restriction. These results provide evidence for the induction of peroxisomal enzymes by low sodium intake.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 31 (8), 2917-2919, 1983

  公益社団法人 日本薬学会

キーワード

• rat kidney cortex

詳細情報

• CRID: 1390001204162374272
• NII論文ID: 130003769407
• DOI: 10.1248/cpb.31.2917
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 6140085
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/31/8/31_8_2917/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可