Studies on amino acid derivatives. V. Synthesis of pyridobenzazoles.

• 千葉 卓男

• 高橋 工

• 金子 主税

抄録

Ethyl 2-benzimidazoleacetate (2a) reacted with 4-ethoxymethylene-2-phenyl-5-oxazolone (1) to give 2-benzamido-4-ethoxycarbonyl-1-oxo-1, 5-dihydropyrido [1, 2-α] benzimidazole (5a). Similar reactions of ethyl 2-benzoxazoleacetate (3a) or ethyl 2-benzothiazoleacetate (4a) with compound 1 gave the corresponding pyridobenzazoles, i.e., pyrido [2, 1-b] benzoxazole (6a) and pyrido [2, 1-b]-benzothiazole (7a), respectively. 2-Cyanomethyl-(2b, 3b, and 4b) and 2-acetonyl-benzazole derivatives (2c, 3c, and 4c), if used in the above reactions instead of 2-ethoxycarbonyl derivatives (2a, 3a, and 4a), gave the corresponding pyridobenzazole derivatives (5b, 6b, 7b, 5c, 6c, and 7c).

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 33 (9), 4002-4004, 1985

  公益社団法人 日本薬学会

キーワード

• intramolecular acylation

詳細情報

• CRID: 1390282679144078848
• NII論文ID: 130003770410
• DOI: 10.1248/cpb.33.4002
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/33/9/33_9_4002/_pdf
• 本文言語コード: en
• データソース種別:
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• 抄録ライセンスフラグ: 使用不可