SUPPRESSION OF DELAYED HYPERSENSITIVITY BY MEASLES VIRUS INFECTION IN GUINEA PIGS

• 山内 一也

  東京大学医科学研究所

• 大田 博昭

  バイオ製薬栃木ラボ

• 片岡 哲朗

  国立予防衛生研究所結核部

• 小船 富美夫

  国立予防衛生研究所麻疹ウイルス部

• 吉川 泰弘

  東京大学医科学研究所

• 徳永 徹

  国立予防衛生研究所結核部

書誌事項

タイトル別名

• Suppression of Delayed Hypersensitivity

抄録

A guinea pig model of mild measles virus infection was established by the intranasal inoculation with Toyoshima strain. The infection was confirmed by the development of both humoral and cell-mediated immunities to measles virus as well as by the demonstration of transient virus growth in the lymphoid tissues. The virus infection caused a transient suppression of delayed hypersensitivity to purified protein derivative (PPD) at both the induction and expression phases, whereas Jones-Mote-type hypersensitivity to ovalbumin developed in a normal fashion. In the virus-infected animals, the suppressed response to the skin reacting factor was observed as well, however in vitro responsiveness of lymphocytes to PPD was not suppressed. On the other hand, transient enhancement of skin reactivity to phytohemagglutinin by virus infection was noticed. These results may indicate subtle alterations of immune functions in guinea pigs during measles virus infection.

収録刊行物

• Ｊａｐａｎｅｓｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ　ａｎｄ　Ｂｉｏｌｏｇｙ

  Ｊａｐａｎｅｓｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ　ａｎｄ　Ｂｉｏｌｏｇｙ 34 (2), 81-94, 1981

  国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会

キーワード

• General Biochemistry, Genetics and Molecular Biology

詳細情報

• CRID: 1390282681218004096
• NII論文ID: 130003778347
• NII書誌ID: AA1132885X
• DOI: 10.7883/yoken1952.34.81
• COI: 1:STN:280:DyaL38%2FnvVGitA%3D%3D
• ISSN: 18842828
• ISSN: 00215112
• NDL書誌ID: 2348129
• PubMed: 7311110
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I2348129
• Web Site: https://search.jamas.or.jp/link/ui/1982146086
• 本文言語コード: en
• データソース種別:
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  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可