Building a Knowledge-Base for Protein Function Prediction using Multistrategy Learning

DOI

抄録

Conventional techniques for protein function prediction using similarities of amino acid sequences enable us to only classify the protein functions into function groups. They usually fail to predict specific protein functions. To overcome the limitation, in this paper, we propose a method for protein function prediction using functional feature analysis and a multistrategy learning approach to building the knowledge-base. By “functional feature”, we mean a feature of an amino acid sequence characterizing the function of a protein with the amino acid sequence. They are secondary and/or tertiary structures of amino acid sequences that corresponds to functional elements comprising the functions of a protein. The functional features are extracted from amino acid sequences using Abductive inference, Inductive inference, and Deductive inference. In this paper, we show the effectiveness of the method by an example problem to classify functions of bacteriorhodopsin-like proteins.

収録刊行物

詳細情報 詳細情報について

  • CRID
    1390282679467468544
  • NII論文ID
    130003812287
  • DOI
    10.11234/gi1990.6.39
  • ISSN
    2185842X
    09199454
  • 本文言語コード
    en
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

問題の指摘

ページトップへ