舌背粘膜の実験的熱傷の治癒過程について　組織ならびに微細血管構築の修復

• 方 一如

  大阪歯科大学解剖学講座

• 諏訪 文彦

  大阪歯科大学解剖学講座

書誌事項

タイトル別名

• Sequential changes during the healing of an experimental burn on the lingual dorsum. Tissue restoration and microvascular architecture.
• Tissue restoration and microvascular architecture
• 組織ならびに微細血管構築の修復

抄録

This study was made in attempt to pursure sequential changes of the microvasculature and tissue restoration during the healing of an experimental burn (Second degree burn of the skin) on the lingual dorsum of the rat utilizing microcorrosion castings by scanning electron microscopy. This healing process could be classified into five stages; 1) blister formation, 2) blister involution, 3) ulceration, 4) earlier and 5) later epithelial restoration. In the 1st stage, blood capillaries in the lamina propria were dilated and the cross striations of the muscle fiber disappeared. Arrangement of the simple conical papillae became irregular, meshworks of the interpapillary venular network were enlarged and intercrural distance of the capillary loops was increased. In the 2nd stage, the blister epithelium fell off and the lamina propria and capillary loops beneath it diasappered. Although the mucous membrane was broken, these papillae remained. In the center of the burn wound, arterioles and venules were exposed since capillary loops of the papillae and the lamina propria arteriolar and venular networks disappeared. In the 3rd stage, a swelling of the wound margin, radiating grooves on the wound surface and a recess in the wound center were observed. Capillary loops of the papillae in the wound margin have inclined toward the wound center. Also tops of the loops were swollen. In the 4th stage, the mucous membrane of the wound margin was extended all over the wound. The epithelial, propria and submucous layers, became clear. A groove crossing the wound surface was observed. The papillae and vascular network were formed newly from the wound margin toward the center. This network was formed from pre-existing capillaries of the wound margin and newly-formed capillaries from the wound bottom, anastomosing with one another, and developed to newly-formed capillary loops. The network became dense in the wound center. In the last stage, the wound surface was cicatrized. The lamina propria was still composed of immature connective tissue, but the wound was covered with newly-formed papillae similar to those in control rats. Newly-formed capillary loops were observed in the wound margin and center. A complete restoration of the burn wound has taken about six weeks viewed from the healing of tissue and microvasculature.

収録刊行物

• 歯科基礎医学会雑誌

  歯科基礎医学会雑誌 35 (4), 323-337, 1993

  歯科基礎医学会

キーワード

• restoration
• burn
• microvascularization
• microvascuclar casts
• rat

詳細情報

• CRID: 1390282679659932544
• NII論文ID: 130003815321
• DOI: 10.2330/joralbiosci1965.35.323
• ISSN: 03850137
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可