Localization of Ebk/MDK1 in Mouse Oral Development

• Shimizu Takehiko

  Department of Pediatric Dentistry, Nihon University School of Dentistry at Matsudo

• Maeda Takahide

  Department of Pediatric Dentistry, Nihon University School of Dentistry at Matsudo

抄録

The Ebk/MDK1 gene belongs to the receptor tyrosine kinase (RTKs) family and has been shown to be closely related to the Eph/Eck/Elk subfamily. A study was conducted to investigate the role of Ebk/ MDK1 in the oral development of early mouse embryogenesis. RT-PCR analysis identified the presence of Ebk/MDK1 mRNA in the region of the first molar at embryonic day 15 (E15). In situ hybridization analysis in the developing oral field from E12 to E16 revealed Ebk/MDK1 expressed in the mesenchyme underlying the dental epithelium of both of the first molars and incisors, as well as in the mesenchyme of the developing alveolar ridge, palate, tongue and lip. The distinct patterns of Ebk/MDK1 expression suggest that this gene may be involved in the establishment of these oral structures in mouse embryogenesis.

収録刊行物

• 歯科基礎医学会雑誌

  歯科基礎医学会雑誌 45 (2), 52-58, 2003

  歯科基礎医学会

キーワード

• Ebk
• MDK1
• receptor tyrosine kinase
• tooth development
• oral development
• mouse

詳細情報

• CRID: 1390282679660056704
• NII論文ID: 130003815478
• NII論文ID: 110003166806
• NII書誌ID: AN00100090
• DOI: 10.2330/joralbiosci1965.45.52
• ISSN: 03850137
• Web Site: https://search.jamas.or.jp/link/ui/2004066078
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可