数種のグアニジン塩及びその誘導体の伝染性軟化病に対する発病抑制効果

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タイトル別名
  • Inhibitory effects of several guanidine salts and derivatives on the incidence of infectious flacherie in the silkworm, Bombyx mori.
  • 伝染性軟化病に対するグアニジンの発病抑制効果について　ＩＶ　　数種のグアニジン塩及びその誘導体の伝染性軟化病に対する発病抑制効果
  • スウシュ ノ グアニジンエン オヨビ ソノ ユウドウタイ ノ デンセンセイ ナ
  • 伝染性軟化病に対するグアニジンの発病抑制効果について IV

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抄録

In previous papers, we reported that guanidine hydrochloride has an inhibitory effect on the incidence of infectious flacherie in the silkworm, Bonbyx mori. In this paper, several salts of guanidine and derivatives were tested for their inhibitory effects on the disease. Of these chemicals, guanidine carbonate, guandine nitrate, guanidine phosphate and guanidine sulfamate reduced the incidence of infectious flacherie in the same way as guanidine hydrochloride did. On the other hand, sulfaguanidine, dodecylguanidine acetate and octylguanidine acetate, which do not dissociate into guanidile radicals, failed to reduce it. When guanidine carbonate was heated at 200°C for 1 hour to decompose the guanidile radicals, it lost its inhibitory effect on the virus.<br>From these results, it is suggested that the antiviral activity of several guanidine salts on the infectious flacherie virus is associated with the guanidile radical.

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