チアプロフェン酸による光線過敏症

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タイトル別名
  • Photosensitivity to tiaprofenic acid.

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The skin safety of tiaprofenic acid creampreparedby the Japan Roussel Co. was evaluatedwith prophetic patch tests and photopatchtests in twenty healthy volunteers and 24patients with contact dermatitis. Five and 10% of tiaprofenic acid cream were found toshow a strong skin irritation. Thus, 1 to 4% of tiaprofenic acid cream, cream vehicle, 3% tiaprofenic acid in petrolatum and indomethacin cream® as a control were patch- andphotopatch-tested. Positive photopatch testreactions to tiaprofenic acid were seen in 2 outof the 24 patients 2 weeks later, althoughnone showed positive reactions next day afterthe units were removed. It was considered to bea flare-up reaction. In 15 out of the 20 volunteers, patch and photopatch-testings were carriedout two times at a 15 days' interval, and then 200 mg of tiaprofenic acid was administeredorally 15 days later. Positive reactions wereconfirmed at sites photopatch-tested with tiaprofenicacid in 2 volunteers 2 days later. Thewhole tests in volunteers were performed at the Osaka Pharmacology Research Clinic (OPHAC). The 2 volunteers who revealed positive reactionsvisited our clinic, and photosensitivity totiaprofenic acid was confirmed with diagnosticphotopatch test. In addition, a 67-year-oldman with confirmed tiaprofenic acid eruptionswas patch- and photopatch-tested with tiaprofenicacid 1 month after the disease cleared, and found to show positive photopatch testreactions.

収録刊行物

  • 皮膚

    皮膚 29 (3), 586-593, 1987

    日本皮膚科学会大阪地方会

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