書誌事項
- タイトル別名
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- Alloimmunization Rate and Its Risk Factors in Recent Trasfusions Using Leukocyte-Reduction Filters. Prospective Study.
- PROSPECTIVE STUDY
- プロスペクティブ研究
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抄録
Seventy-eight patients multitransfused using leukocyte-reduction filters at bedside were prospectively studied to determine the rate of post-transfusion alloimmunization and its risk to platelet transfusion. HLA- and HPA-antibodies were detected by standard lymphocytotoxicity test (LCT), antihuman globulin-lymphocytotoxicity test (AHG-LCT) and mixed passive haemagglutination method (MPHA).<br>Of these 78 patients, all of whom had a negative antibody screening on admission, 11 (14%) developed HLA antibodies but only one (1%) developed an HPA antibody. HLA antibodies were detected in 9 (24%) of 38 patients with previous transfusion, pregnancy or both but in only 2 (5%) of 40 patients with no presensitization (p<0.02). Among children (<20 years), one (3%) of 35 patients developed HLA antibodies whereas 10 (23%) of 43 adult patients (≥20 years) developed HLA antibodies (p<0.01). An HPA antibody (anti-HPA-2b) was detected with multireactive HLA antibodies in a woman with previous pregnancy.<br>We conclude that WBC-reduced transfusions decrease primary immunization for HLA and HPA antigens. In presensitized adults, however, these transfusions may provide sufficient antigenic stimulation to boost or sustain a secondary alloimmune response. Women with previous pregnancy were identified as a high-responder group with regard to alloimmunization.
収録刊行物
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- 日本輸血学会雑誌
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日本輸血学会雑誌 46 (1), 7-11, 2000
一般社団法人 日本輸血・細胞治療学会
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詳細情報 詳細情報について
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- CRID
- 1390282679884504320
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- NII論文ID
- 130003853145
- 10010139310
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- NII書誌ID
- AN00198368
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- ISSN
- 18838383
- 05461448
- http://id.crossref.org/issn/05461448
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可