酢酸透析と重炭酸透析におけるヘモグロビンの酸素親和性に関する研究

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  • Comparison of the oxygen affinity of hemoglobin between acetate and bicarbonate hemodialysis

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The oxygen affinity of hemoglobin is important in determining tissue oxygenation, and was shown to be decreased in chronic renal failure to compensate nephrogenic anemia. Acetate hemodialysis (AD) has been reported to increase the oxygen affinity of hemoglobin. What effect bicarbonate hemodialysis (BD) might have, however, was not known. The present study was performed to compare the oxygen affinity of hemoglobin in AD and BD in 8 patients on maintenance hemodialysis.<BR>Serum inorganic phosphorus was decreasd, and red blood cell, 3-diphosphoglycerate showed no change during hemodialysis by either method. There was a significant decrease in P50 (in vivo), an inverse value of the oxygen affinity of hemoglobin, during AD, and a tendency to decrease during BD. The changes in P50 (in vivo) during AD and BD were not significantly different. P50 (in vitro) showed no change during either type of hemodialysis.

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