近交系マウス間における日本脳炎ウイルス末梢接種による感受性の差異

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  • 松尾 幸子
    長崎大学熱帯医学研究所附属熱帯性病原体感染動物実験施設 長崎大学熱帯医学研究所ウイルス学部門
  • 森田 公一
    長崎大学熱帯医学研究所ウイルス学部門
  • 森田分藤 桂子
    長崎大学熱帯医学研究所ウイルス学部門
  • 五十嵐 章
    長崎大学熱帯医学研究所ウイルス学部門

書誌事項

タイトル別名
  • Differences in Susceptibility to Peripheral Infection with Japanese Encephalitis Virus among Inbred Strains of Mouse.
  • キンコウケイ マウスカン ニ オケル ニホン ノウエン ウイルス マッショウ

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抄録

We compared susceptibility of inbred mouse strains against intracerebral as well as peripheral challenge of a flavivirus, Japanese encephalitis (JE) virus, and the results were summarized as follows:<br>(1) Seven inbred mouse strains (C3H/He, C57BL/6, BALB/c, AKR/N, NC, NZB, DBA/2) could be classified into following 3 groups by their mortality and infection rate when they were subcutaneously challenged with a wild JE virus strain isolated from field-caught mosquitoes at a single passage in mouse (B18AM, B-1): [1] high mortality and high infection rate (C3H/He, C57BL/6, AKR/N), [2] low mortality but high infection rate (BALB/c, NC, NZB), and [3] low mortality and low infection rate (DBA/2). The DBA/2 strain showed lowest mortality and infection rate with statistically significant difference with other strains.<br>(2) Three inbred mouse strains (C3H/He, C57BL/6, BALB/c) were peripherally challenged with following 6 different wild strains of JE virus: mosquito origin after a single passage in mouse (B-1); mosquito origin after 30 passages in mice by subcutaneous inoculations (BP-30), mosquito origin after 30 passages in mice by intracerebral inoculations (BB-30); human origin after a single passage in mouse (JaNH180, J-1); human origin after 30 passages in mice by subcutaneous inoculations (JP-30); human origin after 30 passages in mice by intracerebral inoculations (JB-30). Survival of these inbred mice showed curves, with statistical difference among mouse strains. Anti-JE ELISA antibody titers in survived mice were lowest in BALB/c among 3 inbred mouse strains for all JE virus strains used to the challenge experiment. The result indicated that BALB/c would be a suitable host to study inapparent JE virus infection which is frequent among humans exposed to JE virus.<br>(3) Male mice showed higher mortality than females when 4 weeks old mice were peripherally challenged by JE virus, and the difference was statistically significant.<br>The results as a whole indicated that the susceptibility of mice to JE virus is under the control of genetic factors.

収録刊行物

  • ウイルス

    ウイルス 44 (2), 205-215, 1994

    日本ウイルス学会

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