MHCクラスII分子を介したシグナル伝達と免疫制御

• 松下 祥

  熊本大学大学院医学研究科免疫識別学教室

書誌事項

タイトル別名

• <I>Signaling through class II MHC molecules</I>
• -<I>Ir-genes revisited</I>-
• ―免疫応答遺伝子再訪―

抄録

Signals transmitted by class II MHC molecules are important regarding cell function related to antigen presentation. Cross-linking HLA-DR molecules on B cells led to an increased production of IgM, with an enhanced expression of both membrane-and secretory-type IgM heavy chain mRNA. Increased IgM production was also observed in TCR-peptide-HLA-DR interaction, without the involvement of CD40-CD154 interaction. This event was inhibited specifically by piceatannol but not by PP 2, and ligation of HLA-DR on B cells enhanced Syk activity. Thus, HLA-DR molecules on B cells not only present antigenic peptides to T cells, but also upregulate IgM production, in association with Syk activation. We next found that peptide-pulsed monocytes preferentially produce proinflammatory monokines, by interacting with emetine-treated and DR-restricted T cells, whereas both DQ-restricted and DP-restricted T cells stimulated relatively higher levels of antiinflammatory monokine IL-10. Moreover, activation patterns of MAP kinases by anti-DR, anti-DQ and anti-DP Abs were distinct, which was further evidenced by the effect of MAP kinase inhibitors. HLA-DR, -DQ and -DP molecules may transmit distinct signals into monocytes through distinct MAP kinases and are functionally heterogeneous, which provide a clue to the need for generation of a multigene family of class II MHC.

収録刊行物

• 炎症・再生

  炎症・再生 21 (5), 541-555, 2001

  一般社団法人 日本炎症・再生医学会

キーワード

• <I>HLA</I>
• <I>Ir-genes</I>
• <I>MAP kinases</I>
• <I>Syk</I>
• <I>monokines</I>

詳細情報

• CRID: 1390282680158254464
• NII論文ID: 130003855378
• DOI: 10.2492/jsir.21.541
• ISSN: 18805795
• ISSN: 13468022
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可